Cancer Specific Glycosylation Of Cd13 Impacts Its Detection And Activity In Preclinical Cancer

By switzerlandersing On Sep 10, 2025

Site-specific Characterization Of N-glycosylation In CD133 By MS... | Download Scientific Diagram

Site-specific Characterization Of N-glycosylation In CD133 By MS... | Download Scientific Diagram We identify cancer specific o glycosylation of cd13, which selectively blocks its detection in cancer models but not in normal tissues. in addition, the metabolism activity of cancer expressed cd13 was observed to be critically dependent on its unique glycosylation. Supplemental information cancer specific glycosylation of cd13 impacts its detection and activity in preclinical cancer tissues francis m. barnieh, sebastian p. galuska, paul m. loadman, simon ward, robert a. falconer, and sherif f. el khamisy.

CD133 Is An Independent Predictive And Prognostic Marker In Metastatic Breast Cancer - IOS Press

CD133 Is An Independent Predictive And Prognostic Marker In Metastatic Breast Cancer - IOS Press We identify cancer specific o glycosylation of cd13, which selectively blocks its detection in cancer models but not in normal tissues. in addition, the metabolism activity of cancer expressed cd13 was observed to be critically dependent on its unique glycosylation. We isolated glycoproteins that bind e selectin from the cf1 t breast cancer cell line, derived from a patient with ductal carcinoma. Increased expression or activity of apn/cd13 has been described for various tumors, such that apn/cd13 is in most cases associated with reduced disease free and overall survival. the mechanisms that mediate these cellular effects of apn/cd13 have been largely determined and are described here. The roles of glycans are highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention.

Figure 2 From CD13 Is A Therapeutic Target In Human Liver Cancer Stem Cells. | Semantic Scholar

Figure 2 From CD13 Is A Therapeutic Target In Human Liver Cancer Stem Cells. | Semantic Scholar Increased expression or activity of apn/cd13 has been described for various tumors, such that apn/cd13 is in most cases associated with reduced disease free and overall survival. the mechanisms that mediate these cellular effects of apn/cd13 have been largely determined and are described here. The roles of glycans are highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. Matsuki, monoclonal antibodies with defined recognition sequences in the stem region of cd44: detection of differential glycosylation of cd44 between tumor and stromal cells in tissue, cancer res., № 63, с. 8278. While hcell expression in breast cancer has been previously reported, this is the first study indicating that cd13 functions as an e selectin ligand in breast cancer. Cancer specific glycosylation of cd13 impacts its detection and activity in preclinical cancer tissues. Increased expression or activity of apn/cd13 has been described for various tumors, such that apn/cd13 is in most cases associated with reduced disease free and overall survival. the mechanisms that mediate these cellular effects of apn/cd13 have been largely determined and are described here.

Table 1 From Potential Mechanisms Of CD133 In Cancer Stem Cells | Semantic Scholar

Table 1 From Potential Mechanisms Of CD133 In Cancer Stem Cells | Semantic Scholar Matsuki, monoclonal antibodies with defined recognition sequences in the stem region of cd44: detection of differential glycosylation of cd44 between tumor and stromal cells in tissue, cancer res., № 63, с. 8278. While hcell expression in breast cancer has been previously reported, this is the first study indicating that cd13 functions as an e selectin ligand in breast cancer. Cancer specific glycosylation of cd13 impacts its detection and activity in preclinical cancer tissues. Increased expression or activity of apn/cd13 has been described for various tumors, such that apn/cd13 is in most cases associated with reduced disease free and overall survival. the mechanisms that mediate these cellular effects of apn/cd13 have been largely determined and are described here.